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Multi Drug Resistant Organism Infections (MDRO) - a priority healthcare-associated infection

General Resources

Sample Tools - Apply/Take Action

CDC CRE Toolkit. Carbapenem-resistant Enterobacteriaceae (CRE) are a serious threat to public health. Infections with CRE are difficult, and in some cases impossible, to treat and have been associated with mortality rates up to 50%(1). To help protect patients and prevent transmission, CDC has released a CRE toolkit which expands on the 2009 CDC recommendations and continues to be updated as new information becomes available.

NHSN Reporting Tools for C. difficile, MRSA, and other Drug-resistant Infections

References/Guidelines/Standards

AHRQ Universal ICU Decolonization: An Enhanced Protocol. The REDUCE MRSA Trial (Randomized Evaluation of Decolonization vs. Universal Clearance to Eliminate Methicillin-Resistant Staphylococcus aureus) found that universal decolonization was the most effective intervention to reduce MRSA infections. This enhanced protocol provides instructions for implementing universal decolonization in adult intensive care units.

HICPAC Management of Multidrug-Resistant Organisms. In Healthcare Settings, 2006 Guidelines Successful control of MDROs has been documented in the United States and abroad using a variety of combined interventions. These include improvements in hand hygiene, use of Contact Precautions until patients are culture-negative for a target MDRO, active surveillance cultures (ASC), education, enhanced environmental cleaning, and improvements in communication about patients with MDROs within and between healthcare facilities.

MDH General CRE. CRE Information for health professionals from the Minnesota Department of Health.

MDH MRSA Guidelines and Resources. From the Minnesota Department of Health.

MDH Recommendations for the Prevention and Control of CRE in Acute and Long-term Acute Care Hospitals. From the Minnesota Department of Health.

MDH Recommendations for the Prevention and Control of CRE in Long-term Care Facilities. From the Minnesota Department of Health.

MDH Recommendations for the Prevention and Control of MRSA in acute care facilities. From the Minnesota Department of Health.

MDRO Management Guidelines. (74-page PDF)

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CHAIN is an effort lead by the Association for Professionals in Infection Control and Epidemiology-Minnesota (APIC MN), Minnesota Department of Health, Minnesota Hospital Association, and Stratis Health, which represents Lake Superior Quality Innovation Network in Minnesota.