Multi Drug Resistant Organism Infections (MDRO) - a priority healthcare-associated infection

General Resources

Sample Tools - Apply/Take Action

. Carbapenem-resistant Enterobacteriaceae (CRE) are a serious threat to public health. Infections with CRE are difficult, and in some cases impossible, to treat and have been associated with mortality rates up to 50%(1). To help protect patients and prevent transmission, CDC has released a CRE toolkit which expands on the 2009 CDC recommendations and continues to be updated as new information becomes available.

References/Guidelines/Standards

. The REDUCE MRSA Trial (Randomized Evaluation of Decolonization vs. Universal Clearance to Eliminate Methicillin-Resistant Staphylococcus aureus) found that universal decolonization was the most effective intervention to reduce MRSA infections. This enhanced protocol provides instructions for implementing universal decolonization in adult intensive care units.

. In Healthcare Settings, 2006 Guidelines Successful control of MDROs has been documented in the United States and abroad using a variety of combined interventions. These include improvements in hand hygiene, use of Contact Precautions until patients are culture-negative for a target MDRO, active surveillance cultures (ASC), education, enhanced environmental cleaning, and improvements in communication about patients with MDROs within and between healthcare facilities.

. CRE Information for health professionals from the Minnesota Department of Health.

. From the Minnesota Department of Health.

. From the Minnesota Department of Health.

. From the Minnesota Department of Health.

. From the Minnesota Department of Health.

. (74-page PDF)